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KMID : 0921620220520040137
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Journal of Bacteriology and Virology
2022 Volume.52 No. 4 p.137 ~ p.144
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Molecular Epidemiological Study of Measles Cases in Gyeonggi Province
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Han Baek-Sang
Moon Su-Kyong
Park Sin-Hee
Ryu Kyong-Shin
Kim Eun-Bee
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Abstract
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Measles is one of the highly contagious infectious diseases in which about 90% of the groups that have no immunity against measles are infected when exposed to the measles virus. Even after the Republic of Korea was certified as a ‘national measles eradication’ by the WHO in March 2014, two import-related outbreaks of measles occurred in 2014 and 2019. In this study, we analyzed epidemiological characteristics and genetic distribution of measles cases. Ninety-eight nasopharyngeal or oropharyngeal swab samples that confirmed cases of measles in Gyeonggi province in 2019 were conducted genotyping assay and sequence analysis. Fifty cases were classified as group outbreak-related cases and Forty-eight cases were classified as sporadic cases. As a result of genetic analysis, these cases were classified into D8, B3, and A genotypes, and except for the A type which was known as the vaccine type, D8 and B3 types were identified as import-related measles viruses. As with these results, for the complete eradication of measles, not only a high-quality surveillance system but also molecular epidemiological analysis data must be supported. The results of this study are expected to be used as important data for establishing a quarantine system through the accumulation of measles virus genotyping data and case reports data in the future when measles occurs in South Korea.
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KEYWORD
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Measles virus, Molecular epidemiology, Genotype, Sequence analysis
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